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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAvdwLXo_FK6rffbzDpCOQrqEOXT-XKxd_j7jYFBNPsAg#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAvdwLXo_FK6rffbzDpCOQrqEOXT-XKxd_j7jYFBNPsAg#_6 http://www.w3.org/ns/prov#value We show that upon CD40 antibody-mediated cross-linking, APE/Ref-1 translocates from the cytoplasm to the nucleus of activated B cells, where it modulates the DNA binding activity of both Pax5a and EBF. Moreover, we show that the repression of APE/Ref-1 protein production is able to block CD40-mediated Pax5a activation. We also provide evidence that APE/Ref-1 can modulate the cooperative activation of the blk promoter operated by Pax5a and EBF and that APE/Ref-1 might directly regulate EBF functional activity. Finally, we show that the interaction between Pax5a and EBF enhances EBF binding activity to its consensus sequence, suggesting that Pax5a can physically interact with EBF and modulate its DNA binding activity. http://www.tkuhn.ch/bel2nanopub/RAvdwLXo_FK6rffbzDpCOQrqEOXT-XKxd_j7jYFBNPsAg#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14594818 http://www.tkuhn.ch/bel2nanopub/RAvdwLXo_FK6rffbzDpCOQrqEOXT-XKxd_j7jYFBNPsAg#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAvdwLXo_FK6rffbzDpCOQrqEOXT-XKxd_j7jYFBNPsAg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14594818 http://www.tkuhn.ch/bel2nanopub/RAvdwLXo_FK6rffbzDpCOQrqEOXT-XKxd_j7jYFBNPsAg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAvdwLXo_FK6rffbzDpCOQrqEOXT-XKxd_j7jYFBNPsAg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAvdwLXo_FK6rffbzDpCOQrqEOXT-XKxd_j7jYFBNPsAg#_6 http://www.tkuhn.ch/bel2nanopub/RAvdwLXo_FK6rffbzDpCOQrqEOXT-XKxd_j7jYFBNPsAg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAvdwLXo_FK6rffbzDpCOQrqEOXT-XKxd_j7jYFBNPsAg http://purl.org/dc/terms/created 2014-07-03T14:32:11.001+02:00 http://www.tkuhn.ch/bel2nanopub/RAvdwLXo_FK6rffbzDpCOQrqEOXT-XKxd_j7jYFBNPsAg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAvdwLXo_FK6rffbzDpCOQrqEOXT-XKxd_j7jYFBNPsAg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234