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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAvRPMAjauNzbFyoGPocPTCmmlhZX6hSUfxRog_QgMDrA#_3 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAvRPMAjauNzbFyoGPocPTCmmlhZX6hSUfxRog_QgMDrA#_2 http://www.w3.org/ns/prov#value Oxidative and nitrative stress lead to the formation of peroxynitrite, which nitrates tyrosine residues on certain proteins. HDAC2, but not other isoforms of HDAC, shows increased tyrosine nitration in macrophages and peripheral lung of COPD patients and this is correlated with increased expression of IL-8. Nitration of proteins such as HDAC2 leads to their ubiquitination, which marks them for degradation by the proteasome. \"Oxidative stress reduces histone deacetylase 2 activity\"; \"Peroxynitrite and SIN-1, a peroxynitrite generator, were also able to reduce HDAC2 activity via tyrosine nitration.\"--ref 16 http://www.tkuhn.ch/bel2nanopub/RAvRPMAjauNzbFyoGPocPTCmmlhZX6hSUfxRog_QgMDrA#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16865089 http://www.tkuhn.ch/bel2nanopub/RAvRPMAjauNzbFyoGPocPTCmmlhZX6hSUfxRog_QgMDrA#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAvRPMAjauNzbFyoGPocPTCmmlhZX6hSUfxRog_QgMDrA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16865089 http://www.tkuhn.ch/bel2nanopub/RAvRPMAjauNzbFyoGPocPTCmmlhZX6hSUfxRog_QgMDrA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAvRPMAjauNzbFyoGPocPTCmmlhZX6hSUfxRog_QgMDrA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAvRPMAjauNzbFyoGPocPTCmmlhZX6hSUfxRog_QgMDrA#_2 http://www.tkuhn.ch/bel2nanopub/RAvRPMAjauNzbFyoGPocPTCmmlhZX6hSUfxRog_QgMDrA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAvRPMAjauNzbFyoGPocPTCmmlhZX6hSUfxRog_QgMDrA http://purl.org/dc/terms/created 2014-07-03T14:33:02.332+02:00 http://www.tkuhn.ch/bel2nanopub/RAvRPMAjauNzbFyoGPocPTCmmlhZX6hSUfxRog_QgMDrA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAvRPMAjauNzbFyoGPocPTCmmlhZX6hSUfxRog_QgMDrA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234