sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_3 ;
    pav:version "20131211" .
  sub:_2 prov:value "Oxidative and nitrative stress lead to the formation of peroxynitrite, which nitrates tyrosine residues on certain proteins. HDAC2, but not other isoforms of HDAC, shows increased tyrosine nitration in macrophages and peripheral lung of COPD patients and this is correlated with increased expression of IL-8. Nitration of proteins such as HDAC2 leads to their ubiquitination, which marks them for degradation by the proteasome.  \\\"Oxidative stress reduces histone deacetylase 2 activity\\\"; \\\"Peroxynitrite and SIN-1, a peroxynitrite generator, were also able to reduce HDAC2 activity via tyrosine nitration.\\\"--ref 16" ;
    prov:wasQuotedFrom pubmed:16865089 .
  sub:_3 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:16865089 ;
    prov:wasDerivedFrom beldoc: , sub:_2 .
}