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[Previously, tumour-derived heparanase activity (which has been shown to be related to the metastatic potential of murine and human melanoma cell lines) was reported to cleave HS and be inhibited by heparin, as distinct from human platelet heparanase, which cleaved both substrates [Nakajima, Irimura and Nicolson (1988) J.Cell Biochem.36, 157-167].]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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