. . . . . . . . "Loss of endoproteolytic cleavage; reduces production of amyloid beta in APP processing and of NICD in NOTCH1 processing." . "253"^^ . . "253"^^ . . . . . . "Abolishes gamma-secretase activity. Reduces production of amyloid beta in APP processing. Accumulation of full-length PS1. Loss of binding of transition state analog gamma-secretase inhibitor." . "253"^^ . . "253"^^ . . "Mutagenesis site occurs in NX_P49768-2 at amino acids 253 - 253." . . . . . . "neXtProt gold" . . . . . . . . . . . . . "2014-09-19T00:00:00.0Z"^^ . . . "neXtProt database" . "CALIPHO project" . . . . . "1" . . . . .