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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAvHbEh17ECCGeIgRsQS5926MzUOQ8lPwyYgTLKBtnDeA#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAvHbEh17ECCGeIgRsQS5926MzUOQ8lPwyYgTLKBtnDeA#_4 http://www.w3.org/ns/prov#value Rosiglitazone has marked anti-inflammatory effects on macrophages [31]. This led us to examine the effect of aspirin, an anti-inflammatory compound that targets IkB kinase and has insulin-sensitizing effects [32]. Remarkably, aspirin dramatically decreased endotoxin-induced resistin expression in a dose-dependent manner (Figure 4C). Both aspirin (via IkB kinase) and rosiglitazone (via PPARg) inhibit NF-kB [31,32], which is activated by LPS. Indeed, treatment of the macrophages with the proteasome inhibitor MG132, which prevents NF-kB activation [33], abrogated endotoxin-induced activation of resistin expression (data not shown). Moreover, treatment of the macrophages with SN50, a cell-permeable peptide that specifically prevents activation of NF-kB by inhibiting its nuclear translocation [34], nearly abolished endotoxin-induced activation of resistin expression (Figure 4D). Thus, activation of NF-kB is required for LPS induction of resistin in human macrophages. http://www.tkuhn.ch/bel2nanopub/RAvHbEh17ECCGeIgRsQS5926MzUOQ8lPwyYgTLKBtnDeA#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15578112 http://www.tkuhn.ch/bel2nanopub/RAvHbEh17ECCGeIgRsQS5926MzUOQ8lPwyYgTLKBtnDeA#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAvHbEh17ECCGeIgRsQS5926MzUOQ8lPwyYgTLKBtnDeA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15578112 http://www.tkuhn.ch/bel2nanopub/RAvHbEh17ECCGeIgRsQS5926MzUOQ8lPwyYgTLKBtnDeA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAvHbEh17ECCGeIgRsQS5926MzUOQ8lPwyYgTLKBtnDeA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAvHbEh17ECCGeIgRsQS5926MzUOQ8lPwyYgTLKBtnDeA#_4 http://www.tkuhn.ch/bel2nanopub/RAvHbEh17ECCGeIgRsQS5926MzUOQ8lPwyYgTLKBtnDeA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAvHbEh17ECCGeIgRsQS5926MzUOQ8lPwyYgTLKBtnDeA http://purl.org/dc/terms/created 2014-07-03T14:32:35.663+02:00 http://www.tkuhn.ch/bel2nanopub/RAvHbEh17ECCGeIgRsQS5926MzUOQ8lPwyYgTLKBtnDeA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAvHbEh17ECCGeIgRsQS5926MzUOQ8lPwyYgTLKBtnDeA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234