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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAv5jHxwK2unmprYt2T26PZcgdE-obRBSFu3Wj-2g1KsQ#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAv5jHxwK2unmprYt2T26PZcgdE-obRBSFu3Wj-2g1KsQ#_4 http://www.w3.org/ns/prov#value Incubation of PBMCs with 10 microgram/ml anti-CD3 significantly upregulated IL-17 production upto 3.7 fold, and combination of anti-CD3 and anti-CD28 produced more IL-17 (approximately 1.3-1.5 fold) than anti-CD3 alone. Furthermore, treatment with LY294002 and wortmannin, inhibitors of PI3K, and PDTC, NFkB inhibitor markedly blocked the anti-CD3 and anti-CD28 induced IL17 protein and mRNA production in a dose dependent manner. This indicates that CD3 and CD28 induced IL-17 production was mediated by PI3K pathway. http://www.tkuhn.ch/bel2nanopub/RAv5jHxwK2unmprYt2T26PZcgdE-obRBSFu3Wj-2g1KsQ#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15642134 http://www.tkuhn.ch/bel2nanopub/RAv5jHxwK2unmprYt2T26PZcgdE-obRBSFu3Wj-2g1KsQ#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAv5jHxwK2unmprYt2T26PZcgdE-obRBSFu3Wj-2g1KsQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15642134 http://www.tkuhn.ch/bel2nanopub/RAv5jHxwK2unmprYt2T26PZcgdE-obRBSFu3Wj-2g1KsQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAv5jHxwK2unmprYt2T26PZcgdE-obRBSFu3Wj-2g1KsQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAv5jHxwK2unmprYt2T26PZcgdE-obRBSFu3Wj-2g1KsQ#_4 http://www.tkuhn.ch/bel2nanopub/RAv5jHxwK2unmprYt2T26PZcgdE-obRBSFu3Wj-2g1KsQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAv5jHxwK2unmprYt2T26PZcgdE-obRBSFu3Wj-2g1KsQ http://purl.org/dc/terms/created 2014-07-03T14:32:37.446+02:00 http://www.tkuhn.ch/bel2nanopub/RAv5jHxwK2unmprYt2T26PZcgdE-obRBSFu3Wj-2g1KsQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAv5jHxwK2unmprYt2T26PZcgdE-obRBSFu3Wj-2g1KsQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234