http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#Head http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#assertion http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#provenance http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#assertion http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_2 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0003824 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:88042 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_3 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_4 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0042789 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_4 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:97489 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_5 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CL_0000236 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_5 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_3 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_1 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#assertion http://www.w3.org/2000/01/rdf-schema#label cat(p(MGI:Apex1)) -> tscript(p(MGI:Pax5)) http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_6 http://www.w3.org/ns/prov#value We show that upon CD40 antibody-mediated cross-linking, APE/Ref-1 translocates from the cytoplasm to the nucleus of activated B cells, where it modulates the DNA binding activity of both Pax5a and EBF. Moreover, we show that the repression of APE/Ref-1 protein production is able to block CD40-mediated Pax5a activation. We also provide evidence that APE/Ref-1 can modulate the cooperative activation of the blk promoter operated by Pax5a and EBF and that APE/Ref-1 might directly regulate EBF functional activity. Finally, we show that the interaction between Pax5a and EBF enhances EBF binding activity to its consensus sequence, suggesting that Pax5a can physically interact with EBF and modulate its DNA binding activity. http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14594818 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14594818 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#_6 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0 http://purl.org/dc/terms/created 2014-07-03T14:32:11.004+02:00 http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAuxNJh2xPGY81XDUa6HrzB_reXObksEsQVDnGufutyh0 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234