. . . . . . . . . . . . . . . . . "p(MGI:Hipk2) -| tscript(p(MGI:Ctnnb1))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "overexpression of HIPK2 suppresses LEF1/beta-catenin-mediated transcriptional activation of cyclin D1 expression. Our results indicated that HIPK2 suppressed ?-catenin-mediated activation of cyclin D1 (Fig. 3F). The suppressive effect of HIPK2 did not require phosphorylation on the critical Ser/Thr residues of ?-catenin because HIPK2 suppressed the transcriptional activity of a constitutively active form of ?-catenin (CA-?-catenin) in which amino acids 29–48 were deleted (Fig. 3F). Interestingly, the kinase-inactive form of HIPK2 (HIPK2K221A) showed a similar efficacy in suppressing cyclin D1 expression, suggesting that the kinase activity of HIPK2 was dispensable. " . . "Selventa" . . . . "2014-07-03T14:33:12.082+02:00"^^ . . .