. . . . . . . . . . . . . . . . . . "tscript(p(HGNC:PPARGC1A)) => tscript(p(HGNC:THRA))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "UCP-1 expression is under complex regulation; an enhancer element in the 5'flanking region of the ucp-1 gene has been described with putative binding sites for the thyroid hormone receptor, retinoic acid receptors and PPARs, as recently reviewed (Rousset et al. 2004). PPARc is a nuclear receptor essential for adipogenic differentiation in both WAT and BAT (Lowell 1999), that also displays a thermogenic function upon activation, with prostaglandings being the physiological ligands and TZD pharmacological activators (Rosen & Spiegelman 2001). Although b-adrenergic stimulation is the main physiological pathway that induces thermogenesis and UCP-1 expression in BAT, it is likely to be mediated by the induction of the PPARc coactivator (PGC-1), a master coactivator that binds PPARc, PPARa, thyroid hormone receptor and retinoic acid receptors (Puigserver & Spiegelman 2003)." . . "Selventa" . . . . "2014-07-03T14:30:33.535+02:00"^^ . . .