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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAuIJ-OaybHDADTDXQbCuke_nEiQwrEBpc4fxHPPUWHMI#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAuIJ-OaybHDADTDXQbCuke_nEiQwrEBpc4fxHPPUWHMI#_3 http://www.w3.org/ns/prov#value Fibrin production and deposition in tumors and during inflammation is associated with angiogenesis providing a matrix for the migration of endothelial cells [149, 173]. PAI-1 is actively expressed in fibroblasts contacting endothelial cells [174]. Such contact during angiogenesis can only occur after the degradation of the basement membrane in the process of endothelial cell migration. Tumor growth and angiogenesis are also suppressed in vivo in PAI-1 deficient mice, suggesting the potential importance of PAI-1 in tumor angiogenesis [173]. In various malignant tumors including breast cancer, the combination of high levels of uPA and PAI-1 indicates the poorest prognosis [175]. This suggests that synergic effects of PAI-1 and uPA can promote tumor angiogenesis and metastasis. http://www.tkuhn.ch/bel2nanopub/RAuIJ-OaybHDADTDXQbCuke_nEiQwrEBpc4fxHPPUWHMI#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11841347 http://www.tkuhn.ch/bel2nanopub/RAuIJ-OaybHDADTDXQbCuke_nEiQwrEBpc4fxHPPUWHMI#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAuIJ-OaybHDADTDXQbCuke_nEiQwrEBpc4fxHPPUWHMI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11841347 http://www.tkuhn.ch/bel2nanopub/RAuIJ-OaybHDADTDXQbCuke_nEiQwrEBpc4fxHPPUWHMI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAuIJ-OaybHDADTDXQbCuke_nEiQwrEBpc4fxHPPUWHMI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAuIJ-OaybHDADTDXQbCuke_nEiQwrEBpc4fxHPPUWHMI#_3 http://www.tkuhn.ch/bel2nanopub/RAuIJ-OaybHDADTDXQbCuke_nEiQwrEBpc4fxHPPUWHMI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAuIJ-OaybHDADTDXQbCuke_nEiQwrEBpc4fxHPPUWHMI http://purl.org/dc/terms/created 2014-07-03T14:30:01.042+02:00 http://www.tkuhn.ch/bel2nanopub/RAuIJ-OaybHDADTDXQbCuke_nEiQwrEBpc4fxHPPUWHMI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAuIJ-OaybHDADTDXQbCuke_nEiQwrEBpc4fxHPPUWHMI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234