@prefix this: <http://rdf.disgenet.org/resource/nanopub/NP570584.RAuExikQVNVewxMNvIA4rpxv0GRn8LZMJL1PR3fGH0qd8> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/resource/nanopub/> .
@prefix dgn-gda: <http://rdf.disgenet.org/resource/gda/> .
@prefix dgn-void: <http://rdf.disgenet.org/v4.0.0/void/> .

dgn-np:NP570584.RAuExikQVNVewxMNvIA4rpxv0GRn8LZMJL1PR3fGH0qd8130_head {
  this: np:hasAssertion dgn-np:NP570584.RAuExikQVNVewxMNvIA4rpxv0GRn8LZMJL1PR3fGH0qd8130_assertion;
    np:hasProvenance dgn-np:NP570584.RAuExikQVNVewxMNvIA4rpxv0GRn8LZMJL1PR3fGH0qd8130_provenance;
    np:hasPublicationInfo dgn-np:NP570584.RAuExikQVNVewxMNvIA4rpxv0GRn8LZMJL1PR3fGH0qd8130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP570584.RAuExikQVNVewxMNvIA4rpxv0GRn8LZMJL1PR3fGH0qd8130_assertion a np:Assertion .
  
  dgn-np:NP570584.RAuExikQVNVewxMNvIA4rpxv0GRn8LZMJL1PR3fGH0qd8130_provenance a np:Provenance .
  
  dgn-np:NP570584.RAuExikQVNVewxMNvIA4rpxv0GRn8LZMJL1PR3fGH0qd8130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP570584.RAuExikQVNVewxMNvIA4rpxv0GRn8LZMJL1PR3fGH0qd8130_assertion {
  miriam-gene:1958 a ncit:C16612 .
  
  lld:C0027819 a ncit:C7057 .
  
  dgn-gda:DGN072b95b5e5f0523a4a1b8905367609be sio:SIO_000628 miriam-gene:1958, lld:C0027819;
    a sio:SIO_001121 .
}

dgn-np:NP570584.RAuExikQVNVewxMNvIA4rpxv0GRn8LZMJL1PR3fGH0qd8130_provenance {
  dgn-np:NP570584.RAuExikQVNVewxMNvIA4rpxv0GRn8LZMJL1PR3fGH0qd8130_assertion dcterms:description
      "[Our results are summarized as follows: (i) a recombinant HSV (M012) was constructed in which both copies of the gamma(1)34.5 gene were replaced with the bacterial CD gene, under the control of the cellular promoter Egr-1; (ii) M012-infected cells in vitro efficiently convert 5-fluorocytosine (5-FC) to 5-fluorouracil, thereby enhancing cytotoxicity of neighboring, uninfected cells; (iii) both direct and bystander cytotoxicity of murine neuroblastoma and human glioma cell lines after infection with M012 were demonstrated; (iv) direct intracerebral inoculation of A/J mice demonstrated lack of neurotoxicity at doses similar to G207, a gamma(1)34.5-deleted HSV with demonstrated safety in human patient trials and (v) intratumoral injection of M012 into Neuro-2a flank tumors in combination with 5-FC administration significantly reduced tumor growth versus tumors treated with R3659 combined with 5-FC, or treated with M012 alone.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:16990846;
    prov:wasDerivedFrom dgn-void:befree-2016;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-2016 pav:importedOn "2016-02-19"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP570584.RAuExikQVNVewxMNvIA4rpxv0GRn8LZMJL1PR3fGH0qd8130_publicationInfo {
  this: dcterms:created "2016-05-13T12:46:03+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetv3.0rdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v4.0.0.0" .
  
  dgn-void:disgenetv3.0rdf pav:version "v4.0.0" .
}