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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAuDjHnhgZiQ_vdANBIgNYY75j1pjkgnl_KKH2ULFZO0I#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAuDjHnhgZiQ_vdANBIgNYY75j1pjkgnl_KKH2ULFZO0I#_5 http://www.w3.org/ns/prov#value We have cloned the OTK18 promoter region proximal to the transcriptional start site and determined the region responsible (-884/+1) for the basal transcriptional activity in a microglia cell line. Sequential deletion mutation analyses reveal three important response elements: Yingyang-1 (YY1; -805/-777), an HIV-1 response element for promoter activation; FoxD3 (-743/-725), a negative regulatory element; and Ets response element (-725/-707), a basal transcriptional activity response element. HIV-1 infection-induced upregulation of YY1 and c-Ets-1 protein, binding to the promoter region as determined by immunoblotting and chromatin immunoprecipitation and polymerase chain reaction (PCR) assays, and induction of YY1 was also observed in virus-infected monocyte-derived macrophages. Silencing of FoxD3 and YY1 in the cell line by small interfering RNA duplexes specific to these molecules significantly up- and downregulated basal OTK18 promoter activity in FoxD3 and YY1 response element-dependent manners, respectively. http://www.tkuhn.ch/bel2nanopub/RAuDjHnhgZiQ_vdANBIgNYY75j1pjkgnl_KKH2ULFZO0I#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/19034670 http://www.tkuhn.ch/bel2nanopub/RAuDjHnhgZiQ_vdANBIgNYY75j1pjkgnl_KKH2ULFZO0I#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAuDjHnhgZiQ_vdANBIgNYY75j1pjkgnl_KKH2ULFZO0I#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/19034670 http://www.tkuhn.ch/bel2nanopub/RAuDjHnhgZiQ_vdANBIgNYY75j1pjkgnl_KKH2ULFZO0I#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAuDjHnhgZiQ_vdANBIgNYY75j1pjkgnl_KKH2ULFZO0I#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAuDjHnhgZiQ_vdANBIgNYY75j1pjkgnl_KKH2ULFZO0I#_5 http://www.tkuhn.ch/bel2nanopub/RAuDjHnhgZiQ_vdANBIgNYY75j1pjkgnl_KKH2ULFZO0I#pubinfo http://www.tkuhn.ch/bel2nanopub/RAuDjHnhgZiQ_vdANBIgNYY75j1pjkgnl_KKH2ULFZO0I http://purl.org/dc/terms/created 2014-07-03T14:33:29.453+02:00 http://www.tkuhn.ch/bel2nanopub/RAuDjHnhgZiQ_vdANBIgNYY75j1pjkgnl_KKH2ULFZO0I http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAuDjHnhgZiQ_vdANBIgNYY75j1pjkgnl_KKH2ULFZO0I http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234