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Reduces production of amyloid beta in APP processing. Disassembly of the N-cadherin/PS1 complex at the cell surface. Impairs CDH2 processing. http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._2 http://semanticscience.org/resource/SIO_000300 327 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._3 http://semanticscience.org/resource/SIO_000300 327 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._4 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._5 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._4 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._6 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/obo/owl/SO#SO_0001148 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#RangedSequencePosition http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._4 http://www.w3.org/2000/01/rdf-schema#comment Abolishes gamma-secretase activity. Reduces production of amyloid beta in APP processing. Accumulation of full-length PS1. Loss of binding of transition state analog gamma-secretase inhibitor. http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._5 http://semanticscience.org/resource/SIO_000300 327 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._6 http://semanticscience.org/resource/SIO_000300 327 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._6 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._7 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._8 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._7 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._9 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._7 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/obo/owl/SO#SO_0001148 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._7 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#RangedSequencePosition http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._7 http://www.w3.org/2000/01/rdf-schema#comment No effect on caspase cleavage. http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._8 http://semanticscience.org/resource/SIO_000300 327 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._8 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._9 http://semanticscience.org/resource/SIO_000300 327 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._9 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc.assertion http://www.w3.org/2000/01/rdf-schema#comment Mutagenesis site occurs in NX_P49768-6 at amino acids 327 - 327. http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc.seqFeature http://purl.obolibrary.org/obo/#BFO_0000066 http://www.nextprot.org/db/search#NX_P49768-6 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc.seqFeature http://semanticscience.org/resource/SIO_000008 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._1 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc.seqFeature http://semanticscience.org/resource/SIO_000008 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._4 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc.seqFeature http://semanticscience.org/resource/SIO_000008 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._7 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc.seqFeature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/obo/owl/SO#SO_000010 http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc.provenance http://www.nextprot.org/help/quality_criteria/gold http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000205 http://www.nextprot.org/help/quality_criteria/gold http://www.w3.org/2000/01/rdf-schema#label neXtProt gold http://www.nextprot.org/nanopubs#NX_P49768-6_MUTAGEN_327_327.RAu9vhPgZC1uptrqB9EWcsgJJqZ-FDaPWeezArDiNu1Tc._10 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.bioassayontology.org/bao#BAO_0002095 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