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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAtsvK7J5mO854OTNlkDGlRWEYO_6i3JhYZ8_1RTJeaLU#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAtsvK7J5mO854OTNlkDGlRWEYO_6i3JhYZ8_1RTJeaLU#_3 http://www.w3.org/ns/prov#value In alpha(2)M*-stimulated cells, moreover, TFII-I bound to the GRP78 promoter as determined by CHIP assay. We also demonstrate binding of TFII-I to the c-fos promoter, consistent with its role in upregulating c-fos gene expression. In non-lymphoid cells, phosphorylated c-Src is an activator of TFII-I. Ligation of GRP78 on 1-LN cells with alpha(2)M* was followed by tyrosine phosphorylation of c-Src as well as TFII-I. We conclude that alpha(2)M*-induced increase in GRP78 synthesis is caused by transcriptional upregulation of TFII-I which binds to the GRP78 promoter and thus potentiates its cell survival and antipoptotic functions in 1-LN prostate cancer cells. http://www.tkuhn.ch/bel2nanopub/RAtsvK7J5mO854OTNlkDGlRWEYO_6i3JhYZ8_1RTJeaLU#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/19097122 http://www.tkuhn.ch/bel2nanopub/RAtsvK7J5mO854OTNlkDGlRWEYO_6i3JhYZ8_1RTJeaLU#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAtsvK7J5mO854OTNlkDGlRWEYO_6i3JhYZ8_1RTJeaLU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/19097122 http://www.tkuhn.ch/bel2nanopub/RAtsvK7J5mO854OTNlkDGlRWEYO_6i3JhYZ8_1RTJeaLU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAtsvK7J5mO854OTNlkDGlRWEYO_6i3JhYZ8_1RTJeaLU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAtsvK7J5mO854OTNlkDGlRWEYO_6i3JhYZ8_1RTJeaLU#_3 http://www.tkuhn.ch/bel2nanopub/RAtsvK7J5mO854OTNlkDGlRWEYO_6i3JhYZ8_1RTJeaLU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAtsvK7J5mO854OTNlkDGlRWEYO_6i3JhYZ8_1RTJeaLU http://purl.org/dc/terms/created 2014-07-03T14:33:30.884+02:00 http://www.tkuhn.ch/bel2nanopub/RAtsvK7J5mO854OTNlkDGlRWEYO_6i3JhYZ8_1RTJeaLU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAtsvK7J5mO854OTNlkDGlRWEYO_6i3JhYZ8_1RTJeaLU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234