http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_head http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg http://www.nanopub.org/nschema#hasAssertion http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_assertion http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg http://www.nanopub.org/nschema#hasProvenance http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_provenance http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg http://www.nanopub.org/nschema#hasPublicationInfo http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_publicationInfo http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_assertion http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Assertion http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_provenance http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Provenance http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_publicationInfo http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#PublicationInfo http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_assertion http://identifiers.org/ncbigene/10111 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612 http://linkedlifedata.com/resource/umls/id/C0006826 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7057 http://rdf.disgenet.org/gene-disease-association.ttl#DGN04561fb5f7b92e12baa67f9327dc31b4 http://semanticscience.org/resource/SIO_000628 http://identifiers.org/ncbigene/10111 http://rdf.disgenet.org/gene-disease-association.ttl#DGN04561fb5f7b92e12baa67f9327dc31b4 http://semanticscience.org/resource/SIO_000628 http://linkedlifedata.com/resource/umls/id/C0006826 http://rdf.disgenet.org/gene-disease-association.ttl#DGN04561fb5f7b92e12baa67f9327dc31b4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://semanticscience.org/resource/SIO_001121 http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_provenance http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_assertion http://purl.org/dc/terms/description [BRCA1 contains several functional domains that directly or indirectly interact with a variety of proteins via protein-protein interaction; these include tumor suppressors (BRCA2, p53, Rb and ATM), oncogenes (c-Myc, casein kinase II and E2F), DNA damage repair proteins (RAD50 and RAD51), cell cycle regulators (cyclins and cyclin dependent kinases), transcriptional activators and repressors (RNA polymerase II, RHA, histone deacetylase complex and CtIP), DNA damage-sensing complex and mismatch repair proteins (BRCA1- Associated Surveillance Complex; BASC) and signal transducer and activator of transcription (STAT) among others Formation of foci containing BRCA1 by inherited mutations, or epigenetic mechanisms (promoter methylation) in sporadic cancers leads to a loss of DNA repair ability, disrupts the potential to form complexes with other proteins that are crucial for DNA repair pathways.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine. http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_assertion http://purl.org/ontology/wi/core#evidence http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_assertion http://semanticscience.org/resource/SIO_000772 http://identifiers.org/pubmed/12957814 http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_assertion http://www.w3.org/ns/prov#wasDerivedFrom http://rdf.disgenet.org/v2.1.0/void.ttl#befree-20140225 http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_assertion http://www.w3.org/ns/prov#wasGeneratedBy http://purl.obolibrary.org/obo/eco.owl#ECO_0000203 http://rdf.disgenet.org/v2.1.0/void.ttl#befree-20140225 http://purl.org/pav/2.0/importedOn 2014-02-25 http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000212 http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://www.w3.org/2000/01/rdf-schema#comment Gene-disease associations inferred from text-mining the literature. http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://www.w3.org/2000/01/rdf-schema#label DisGeNET evidence - LITERATURE http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_publicationInfo http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg http://purl.org/dc/terms/created 2014-10-02T12:36:38+02:00 http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg http://purl.org/dc/terms/rights http://opendatacommons.org/licenses/odbl/1.0/ http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg http://purl.org/dc/terms/rightsHolder http://rdf.disgenet.org/v2.1.0/void.ttl#IBIGroup http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg http://purl.org/dc/terms/subject http://semanticscience.org/resource/SIO_000983 http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg http://purl.org/net/provenance/ns#usedData http://rdf.disgenet.org/v2.1.0/void.ttl#disgenetrdf http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0001-5999-6269 http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0002-7534-7661 http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0002-9383-528X http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0003-1244-7654 http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg http://purl.org/pav/2.0/createdBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg http://purl.org/pav/2.0/version v2.1.0.0 http://rdf.disgenet.org/v2.1.0/void.ttl#disgenetrdf http://purl.org/pav/2.0/version v2.1.0