@prefix this: <http://rdf.disgenet.org/nanopublications.trig#NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/eco.owl#> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/2.0/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/nanopublications.trig#> .
@prefix dgn-gda: <http://rdf.disgenet.org/gene-disease-association.ttl#> .
@prefix dgn-void: <http://rdf.disgenet.org/v2.1.0/void.ttl#> .

dgn-np:NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_head {
  this: np:hasAssertion dgn-np:NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_assertion;
    np:hasProvenance dgn-np:NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_provenance;
    np:hasPublicationInfo dgn-np:NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_assertion a np:Assertion .
  
  dgn-np:NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_provenance a np:Provenance .
  
  dgn-np:NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_assertion {
  miriam-gene:10111 a ncit:C16612 .
  
  lld:C0006826 a ncit:C7057 .
  
  dgn-gda:DGN04561fb5f7b92e12baa67f9327dc31b4 sio:SIO_000628 miriam-gene:10111, lld:C0006826;
    a sio:SIO_001121 .
}

dgn-np:NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_provenance {
  dgn-np:NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_assertion dcterms:description
      "[BRCA1 contains several functional domains that directly or indirectly interact with a variety of proteins via protein-protein interaction; these include tumor suppressors (BRCA2, p53, Rb and ATM), oncogenes (c-Myc, casein kinase II and E2F), DNA damage repair proteins (RAD50 and RAD51), cell cycle regulators (cyclins and cyclin dependent kinases), transcriptional activators and repressors (RNA polymerase II, RHA, histone deacetylase complex and CtIP), DNA damage-sensing complex and mismatch repair proteins (BRCA1- Associated Surveillance Complex; BASC) and signal transducer and activator of transcription (STAT) among others Formation of foci containing BRCA1 by inherited mutations, or epigenetic mechanisms (promoter methylation) in sporadic cancers leads to a loss of DNA repair ability, disrupts the potential to form complexes with other proteins that are crucial for DNA repair pathways.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:12957814;
    prov:wasDerivedFrom dgn-void:befree-20140225;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-20140225 pav:importedOn "2014-02-25"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP464659.RAtnxWhQLK5bPFcDf8Ayl_z0WjO1i8BiMaxh9ZM5wC1Hg130_publicationInfo {
  this: dcterms:created "2014-10-02T12:36:38+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetrdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v2.1.0.0" .
  
  dgn-void:disgenetrdf pav:version "v2.1.0" .
}