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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAtj8okfpQujtzzmMnNZ7l5FtE1gck03HQud8q73qza4I#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAtj8okfpQujtzzmMnNZ7l5FtE1gck03HQud8q73qza4I#_4 http://www.w3.org/ns/prov#value Alzheimer's disease (AD) remains one of the most challenging brain disorders facing modern medicine. Neuronal loss underlies the pathogenesis of AD and can occur, in part, by oxidative stress, by beta-amyloid peptide (Abeta), and by excitotoxins. The complement cascade, especially C1q, may affect reactive oxygen species (ROS) and mediate neuronal injury during AD. We demonstrate that incubation of neurons with purified C1q results in increased ROS, which can be partially blocked by low concentrations of Abeta. C1q-binding sites on neurons were demonstrated by 125I-C1q-binding and immunofluorescence tests performed on primary neurons. The blocking of neuronal calreticulin by its antibody abrogated ROS by C1q. We suggest that the C1q may be an important factor contributing to neuronal oxidative stress and neuronal demise during AD. http://www.tkuhn.ch/bel2nanopub/RAtj8okfpQujtzzmMnNZ7l5FtE1gck03HQud8q73qza4I#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12576225 http://www.tkuhn.ch/bel2nanopub/RAtj8okfpQujtzzmMnNZ7l5FtE1gck03HQud8q73qza4I#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAtj8okfpQujtzzmMnNZ7l5FtE1gck03HQud8q73qza4I#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12576225 http://www.tkuhn.ch/bel2nanopub/RAtj8okfpQujtzzmMnNZ7l5FtE1gck03HQud8q73qza4I#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAtj8okfpQujtzzmMnNZ7l5FtE1gck03HQud8q73qza4I#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAtj8okfpQujtzzmMnNZ7l5FtE1gck03HQud8q73qza4I#_4 http://www.tkuhn.ch/bel2nanopub/RAtj8okfpQujtzzmMnNZ7l5FtE1gck03HQud8q73qza4I#pubinfo http://www.tkuhn.ch/bel2nanopub/RAtj8okfpQujtzzmMnNZ7l5FtE1gck03HQud8q73qza4I http://purl.org/dc/terms/created 2014-07-03T14:31:58.770+02:00 http://www.tkuhn.ch/bel2nanopub/RAtj8okfpQujtzzmMnNZ7l5FtE1gck03HQud8q73qza4I http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAtj8okfpQujtzzmMnNZ7l5FtE1gck03HQud8q73qza4I http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234