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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAtZl-waCbt7SlFKuKA5Ro94Acu7qFM3wvw1fw3DZ5jS0#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAtZl-waCbt7SlFKuKA5Ro94Acu7qFM3wvw1fw3DZ5jS0#_6 http://www.w3.org/ns/prov#value Treatment of human umbilical vein endothelial cells (HUVEC) with vascular endothelial growth factor (VEGF, 25 ng/ml) promoted tyrosine phosphorylation and activation of KDR which associates with PLC-gamma and phosphorylates at tyrosine residue. This effect was inhibited by SU5416, a specific KDR antagonist. It was also shown that either (N or C-terminal) SH2 may mediate interaction with tyrosine 951 in KDR; tyrosine 1175 also fosters KDR/PLC-gamma interaction. 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