. . . . . . . . . . . . . . . . . . "kin(p(HGNC:KDR)) -> cat(p(SFAM:\"PLCG Family\"))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "Treatment of human umbilical vein endothelial cells (HUVEC) with vascular endothelial growth factor (VEGF, 25 ng/ml) promoted tyrosine phosphorylation and activation of KDR which associates with PLC-gamma and phosphorylates at tyrosine residue. This effect was inhibited by SU5416, a specific KDR antagonist. It was also shown that either (N or C-terminal) SH2 may mediate interaction with tyrosine 951 in KDR; tyrosine 1175 also fosters KDR/PLC-gamma interaction. Treatment with PlGF (Flt1 agonist) had no effect, suggesting that VEGF induces activation of PLC-gamma is mediated via KDR receptor." . . "Selventa" . . . . "2014-07-03T14:31:33.910+02:00"^^ . . .