http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU.Head http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU http://www.nanopub.org/nschema#hasAssertion http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU.assertion http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU http://www.nanopub.org/nschema#hasProvenance http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU.provenance http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU http://www.nanopub.org/nschema#hasPublicationInfo http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU.pubinfo http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU.assertion http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._1 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._2 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._1 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._3 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/obo/owl/SO#SO_0001148 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#RangedSequencePosition http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._1 http://www.w3.org/2000/01/rdf-schema#comment No effect on endoproteolytic cleavage. No effect on APP processing. Impaired NOTCH1 processing. Greatly reduced Abeta42/Abeta40 ratio. http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._10 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._11 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._10 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._12 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._10 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/obo/owl/SO#SO_0001148 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._10 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#RangedSequencePosition http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._10 http://www.w3.org/2000/01/rdf-schema#comment No effect on endoproteolytic cleavage. No effect on APP nor NOTCH1 processing. http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._11 http://semanticscience.org/resource/SIO_000300 431 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._11 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._12 http://semanticscience.org/resource/SIO_000300 431 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._12 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._13 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._14 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._13 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._15 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._13 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/obo/owl/SO#SO_0001148 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._13 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#RangedSequencePosition http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._13 http://www.w3.org/2000/01/rdf-schema#comment No effect on endoproteolytic cleavage. No effect on APP processing. Impaired NOTCH1 processing. Some increase in Abeta42/Abeta40 ratio. http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._14 http://semanticscience.org/resource/SIO_000300 431 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._14 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._15 http://semanticscience.org/resource/SIO_000300 431 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._15 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._2 http://semanticscience.org/resource/SIO_000300 431 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._3 http://semanticscience.org/resource/SIO_000300 431 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._4 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._5 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._4 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._6 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/obo/owl/SO#SO_0001148 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#RangedSequencePosition http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._4 http://www.w3.org/2000/01/rdf-schema#comment No endoproteolytic cleavage. No APP nor NOTCH1 processing. No detectable Abeta. http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._5 http://semanticscience.org/resource/SIO_000300 431 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._6 http://semanticscience.org/resource/SIO_000300 431 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._6 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._7 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._8 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._7 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._9 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._7 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/obo/owl/SO#SO_0001148 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._7 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#RangedSequencePosition http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._7 http://www.w3.org/2000/01/rdf-schema#comment Greatly reduced endoproteolytic cleavage. Very little APP and NOTCH1 processing. Very low levels of Abeta40 and no detectable Abeta42. http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._8 http://semanticscience.org/resource/SIO_000300 431 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._8 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._9 http://semanticscience.org/resource/SIO_000300 431 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._9 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU.assertion http://www.w3.org/2000/01/rdf-schema#comment Mutagenesis site occurs in NX_P49768-2 at amino acids 431 - 431. http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU.seqFeature http://purl.obolibrary.org/obo/#BFO_0000066 http://www.nextprot.org/db/search#NX_P49768-2 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU.seqFeature http://semanticscience.org/resource/SIO_000008 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._1 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU.seqFeature http://semanticscience.org/resource/SIO_000008 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._10 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU.seqFeature http://semanticscience.org/resource/SIO_000008 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._13 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU.seqFeature http://semanticscience.org/resource/SIO_000008 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._4 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU.seqFeature http://semanticscience.org/resource/SIO_000008 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._7 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU.seqFeature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/obo/owl/SO#SO_000010 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU.provenance http://www.nextprot.org/help/quality_criteria/gold http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000205 http://www.nextprot.org/help/quality_criteria/gold http://www.w3.org/2000/01/rdf-schema#label neXtProt gold http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._16 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.bioassayontology.org/bao#BAO_0002095 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._17 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000218 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._18 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.bioassayontology.org/bao#BAO_0002095 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._19 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000218 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._20 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.bioassayontology.org/bao#BAO_0002095 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._21 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000218 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._22 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.bioassayontology.org/bao#BAO_0002095 http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU._23 http://www.w3.org/1999/02/22-rdf-syntax-ns#type 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