@prefix this: <http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU> .
@prefix sub: <http://www.nextprot.org/nanopubs#NX_P49768-2_MUTAGEN_431_431.RAtXL13Yk136NU7yIeUfkTTP2v59cd6PVfhhU7PwjS2HU.> .
@prefix bao: <http://www.bioassayontology.org/bao#> .
@prefix bfo: <http://purl.obolibrary.org/obo/#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix eco: <http://purl.obolibrary.org/obo/eco.owl#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix nx: <http://www.nextprot.org/db/search#> .
@prefix pav: <http://swan.mindinformatics.org/ontologies/1.2/pav/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix range: <http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix so: <http://purl.org/obo/owl/SO#> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 sio:SIO_000053 sub:_2, sub:_3;
    a so:SO_0001148, range:RangedSequencePosition;
    rdfs:comment "No effect on endoproteolytic cleavage. No effect on APP processing. Impaired NOTCH1 processing. Greatly reduced Abeta42/Abeta40 ratio." .
  
  sub:_10 sio:SIO_000053 sub:_11, sub:_12;
    a so:SO_0001148, range:RangedSequencePosition;
    rdfs:comment "No effect on endoproteolytic cleavage. No effect on APP nor NOTCH1 processing." .
  
  sub:_11 sio:SIO_000300 "431"^^xsd:integer;
    a range:StartPosition .
  
  sub:_12 sio:SIO_000300 "431"^^xsd:integer;
    a range:EndPosition .
  
  sub:_13 sio:SIO_000053 sub:_14, sub:_15;
    a so:SO_0001148, range:RangedSequencePosition;
    rdfs:comment "No effect on endoproteolytic cleavage. No effect on APP processing. Impaired NOTCH1 processing. Some increase in Abeta42/Abeta40 ratio." .
  
  sub:_14 sio:SIO_000300 "431"^^xsd:integer;
    a range:StartPosition .
  
  sub:_15 sio:SIO_000300 "431"^^xsd:integer;
    a range:EndPosition .
  
  sub:_2 sio:SIO_000300 "431"^^xsd:integer;
    a range:StartPosition .
  
  sub:_3 sio:SIO_000300 "431"^^xsd:integer;
    a range:EndPosition .
  
  sub:_4 sio:SIO_000053 sub:_5, sub:_6;
    a so:SO_0001148, range:RangedSequencePosition;
    rdfs:comment "No endoproteolytic cleavage. No APP nor NOTCH1 processing. No detectable Abeta." .
  
  sub:_5 sio:SIO_000300 "431"^^xsd:integer;
    a range:StartPosition .
  
  sub:_6 sio:SIO_000300 "431"^^xsd:integer;
    a range:EndPosition .
  
  sub:_7 sio:SIO_000053 sub:_8, sub:_9;
    a so:SO_0001148, range:RangedSequencePosition;
    rdfs:comment "Greatly reduced endoproteolytic cleavage. Very little APP and NOTCH1 processing. Very low levels of Abeta40 and no detectable Abeta42." .
  
  sub:_8 sio:SIO_000300 "431"^^xsd:integer;
    a range:StartPosition .
  
  sub:_9 sio:SIO_000300 "431"^^xsd:integer;
    a range:EndPosition .
  
  sub:assertion rdfs:comment "Mutagenesis site occurs in NX_P49768-2 at amino acids 431 - 431." .
  
  sub:seqFeature bfo:BFO_0000066 nx:NX_P49768-2;
    sio:SIO_000008 sub:_1, sub:_10, sub:_13, sub:_4, sub:_7;
    a so:SO_000010 .
}

sub:provenance {
  <http://www.nextprot.org/help/quality_criteria/gold> a eco:ECO_0000205;
    rdfs:label "neXtProt gold" .
  
  sub:_16 a bao:BAO_0002095 .
  
  sub:_17 a eco:ECO_0000218 .
  
  sub:_18 a bao:BAO_0002095 .
  
  sub:_19 a eco:ECO_0000218 .
  
  sub:_20 a bao:BAO_0002095 .
  
  sub:_21 a eco:ECO_0000218 .
  
  sub:_22 a bao:BAO_0002095 .
  
  sub:_23 a eco:ECO_0000218 .
  
  sub:_24 a bao:BAO_0002095 .
  
  sub:_25 a eco:ECO_0000218 .
  
  sub:assertion prv:usedData <http://www.uniprot.org/uniprot/P49768>;
    wi:evidence <http://www.nextprot.org/help/quality_criteria/gold>;
    a eco:ECO_0000006, eco:ECO_0000200;
    prov:wasDerivedFrom sub:_16, sub:_18, sub:_20, sub:_22, sub:_24;
    prov:wasGeneratedBy sub:_17, sub:_19, sub:_21, sub:_23, sub:_25 .
}

sub:pubinfo {
  this: dcterms:created "2014-09-19T00:00:00.0Z"^^xsd:dateTime;
    dcterms:rights <http://creativecommons.org/licenses/by/3.0/>;
    dcterms:rightsHolder <http://nextprot.org>;
    prv:usedData "neXtProt database";
    pav:authoredBy "CALIPHO project", <http://orcid.org/0000-0001-6710-1373>, <http://orcid.org/0000-0001-6818-334X>,
      <http://orcid.org/0000-0002-1303-2189>, <http://orcid.org/0000-0003-1813-6857>;
    pav:versionNumber "1";
    prov:wasGeneratedBy sub:_26, sub:_27, sub:_28, sub:_29, sub:_30 .
  
  sub:_26 a eco:ECO_0000248 .
  
  sub:_27 a eco:ECO_0000248 .
  
  sub:_28 a eco:ECO_0000248 .
  
  sub:_29 a eco:ECO_0000248 .
  
  sub:_30 a eco:ECO_0000248 .
}