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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAtWi7BiqpV4ezdKcXEpbXAMN8z7ufBuiSxY_rf6OIhPc#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAtWi7BiqpV4ezdKcXEpbXAMN8z7ufBuiSxY_rf6OIhPc#_5 http://www.w3.org/ns/prov#value e have made use of the Lmx1b knockout mouse. Transmission electron micrographs showed that glomerular development in general and the differentiation of podocytes in particular were severely impaired. The glomerular capillary network was poorly elaborated, fenestrae in the endothelial cells were largely missing, and the glomerular basement membrane was split. In addition podocytes retained a cuboidal shape and did not form foot processes and slit diaphragms. Expression of the alpha4 chain of collagen IV and of podocin was also severely reduced. Using gel shift assays, we demonstrated that LMX1B bound to two AT-rich sequences in the promoter region of NPHS2, the gene encoding podocin. http://www.tkuhn.ch/bel2nanopub/RAtWi7BiqpV4ezdKcXEpbXAMN8z7ufBuiSxY_rf6OIhPc#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11956245 http://www.tkuhn.ch/bel2nanopub/RAtWi7BiqpV4ezdKcXEpbXAMN8z7ufBuiSxY_rf6OIhPc#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAtWi7BiqpV4ezdKcXEpbXAMN8z7ufBuiSxY_rf6OIhPc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11956245 http://www.tkuhn.ch/bel2nanopub/RAtWi7BiqpV4ezdKcXEpbXAMN8z7ufBuiSxY_rf6OIhPc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAtWi7BiqpV4ezdKcXEpbXAMN8z7ufBuiSxY_rf6OIhPc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAtWi7BiqpV4ezdKcXEpbXAMN8z7ufBuiSxY_rf6OIhPc#_5 http://www.tkuhn.ch/bel2nanopub/RAtWi7BiqpV4ezdKcXEpbXAMN8z7ufBuiSxY_rf6OIhPc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAtWi7BiqpV4ezdKcXEpbXAMN8z7ufBuiSxY_rf6OIhPc http://purl.org/dc/terms/created 2014-07-03T14:31:48.469+02:00 http://www.tkuhn.ch/bel2nanopub/RAtWi7BiqpV4ezdKcXEpbXAMN8z7ufBuiSxY_rf6OIhPc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAtWi7BiqpV4ezdKcXEpbXAMN8z7ufBuiSxY_rf6OIhPc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234