@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAtUSdiUZ71NC9x-w7fXyoad9OZ2A8Ix8OsVOvccPnFPA> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAtUSdiUZ71NC9x-w7fXyoad9OZ2A8Ix8OsVOvccPnFPA#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
  sub:_1 geneProductOf: mgi:98729 ;
    a Protein: .
  sub:_2 occursIn: obo:CL_0000057 , obo:UBERON_0000945 , species:10090 ;
    rdf:object mesh:D006965 ;
    rdf:predicate belv:decreases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "p(MGI:Tgfbr2) -| path(MESHD:Hyperplasia)" .
}
sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_4 ;
    pav:version "20131211" .
  sub:_3 prov:value "Bhowmick et al. (2004) generated mice with a targeted deletion of TGFBRII in fibroblasts. Such loss of TGF? signaling in the prostate and the forestomach resulted in hyperplasia of the adjacent epithelia with progression to prostatic intraepithelial neoplasia and gastric squamous carcinoma, respectively (Figure 7A). These effects were accompanied by an elevated expression of hepatocyte growth factor (HGF) in the TGFBRII-defective fibroblasts and activation of the HGF receptor Met in adjacent epithelial cells." ;
    prov:wasQuotedFrom pubmed:18662538 .
  sub:_4 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:18662538 ;
    prov:wasDerivedFrom beldoc: , sub:_3 .
}
sub:pubinfo {
  this: dct:created "2014-07-03T14:33:23.722+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}