@prefix this: <http://rdf.disgenet.org/resource/nanopub/NP473543.RAt2js8Grhp32WM8bNht-6HIiCegxK4ubXyv1m8eSwrPM> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/resource/nanopub/> .
@prefix dgn-gda: <http://rdf.disgenet.org/resource/gda/> .
@prefix dgn-void: <http://rdf.disgenet.org/v3.0.0/void/> .

dgn-np:NP473543.RAt2js8Grhp32WM8bNht-6HIiCegxK4ubXyv1m8eSwrPM130_head {
  this: np:hasAssertion dgn-np:NP473543.RAt2js8Grhp32WM8bNht-6HIiCegxK4ubXyv1m8eSwrPM130_assertion;
    np:hasProvenance dgn-np:NP473543.RAt2js8Grhp32WM8bNht-6HIiCegxK4ubXyv1m8eSwrPM130_provenance;
    np:hasPublicationInfo dgn-np:NP473543.RAt2js8Grhp32WM8bNht-6HIiCegxK4ubXyv1m8eSwrPM130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP473543.RAt2js8Grhp32WM8bNht-6HIiCegxK4ubXyv1m8eSwrPM130_assertion a np:Assertion .
  
  dgn-np:NP473543.RAt2js8Grhp32WM8bNht-6HIiCegxK4ubXyv1m8eSwrPM130_provenance a np:Provenance .
  
  dgn-np:NP473543.RAt2js8Grhp32WM8bNht-6HIiCegxK4ubXyv1m8eSwrPM130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP473543.RAt2js8Grhp32WM8bNht-6HIiCegxK4ubXyv1m8eSwrPM130_assertion {
  miriam-gene:3383 a ncit:C16612 .
  
  lld:C0023493 a ncit:C7057 .
  
  dgn-gda:DGN8c6e4e1ec0dce156720f454d12f4a37c sio:SIO_000628 miriam-gene:3383, lld:C0023493;
    a sio:SIO_001121 .
}

dgn-np:NP473543.RAt2js8Grhp32WM8bNht-6HIiCegxK4ubXyv1m8eSwrPM130_provenance {
  dgn-np:NP473543.RAt2js8Grhp32WM8bNht-6HIiCegxK4ubXyv1m8eSwrPM130_assertion dcterms:description
      "[We report the following novel features of homotypic adhesion via leukocyte function-associated antigen-1 (LFA-1)/intracellular adhesion molecule-1 (ICAM-1) pathway that suggest a role for it in cytokine production and rapid proliferation of ATL cells: (1) ATL cells show clustering in a calcium dependent manner, even at the higher concentration; (2) ATL cells consistently and highly express ICAM-1 and an active form of LFA-1, whereas integrin expression, except for LFA-1, is rather lower compared with that of normal CD4+ T cells; (3) ATL cells make conjugate formation within 6 minutes and clustering within 48 hours, both of which are inhibited by the addition of monoclonal antibodies (MoAbs) against LFA-1 and ICAM-1; (4) spontaneous mRNA transcription and protein secretion of both interleukin-1 and parathyroid hormone-related protein are observed consistently in ATL cells, and these productions are inhibited by anti-LFA-1 and anti-ICAM-1 MoAbs but are markedly increased by cross-linking of LFA-1 and ICAM-1 by the immobilized specific MoAbs; and (5) proliferative responses of ATL cells are also inhibited by these MoAbs.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:7662973;
    prov:wasDerivedFrom dgn-void:befree-20150227;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-20150227 pav:importedOn "2015-02-27"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP473543.RAt2js8Grhp32WM8bNht-6HIiCegxK4ubXyv1m8eSwrPM130_publicationInfo {
  this: dcterms:created "2015-08-25T14:42:19+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetv3.0rdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v3.0.0.0" .
  
  dgn-void:disgenetv3.0rdf pav:version "v3.0.0" .
}