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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAt1kzjmNpOexdZB7flxc6pweQ1nE2-6hsN11QDTRGL1M#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAt1kzjmNpOexdZB7flxc6pweQ1nE2-6hsN11QDTRGL1M#_3 http://www.w3.org/ns/prov#value Here, we show that RhoB activity increases in human breast and cervical cancer cell lines after treatment with DNA damaging agents. Furthermore, RhoB activity is necessary for DNA damage-induced cell death, as the stable loss of RhoB protein expression using shRNA partially protects cells and prevents the phosphorylation of c-Jun N-terminal kinases (JNKs) and the induction of the pro-apoptotic protein Bim after IR. http://www.tkuhn.ch/bel2nanopub/RAt1kzjmNpOexdZB7flxc6pweQ1nE2-6hsN11QDTRGL1M#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/21373644 http://www.tkuhn.ch/bel2nanopub/RAt1kzjmNpOexdZB7flxc6pweQ1nE2-6hsN11QDTRGL1M#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAt1kzjmNpOexdZB7flxc6pweQ1nE2-6hsN11QDTRGL1M#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/21373644 http://www.tkuhn.ch/bel2nanopub/RAt1kzjmNpOexdZB7flxc6pweQ1nE2-6hsN11QDTRGL1M#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAt1kzjmNpOexdZB7flxc6pweQ1nE2-6hsN11QDTRGL1M#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAt1kzjmNpOexdZB7flxc6pweQ1nE2-6hsN11QDTRGL1M#_3 http://www.tkuhn.ch/bel2nanopub/RAt1kzjmNpOexdZB7flxc6pweQ1nE2-6hsN11QDTRGL1M#pubinfo http://www.tkuhn.ch/bel2nanopub/RAt1kzjmNpOexdZB7flxc6pweQ1nE2-6hsN11QDTRGL1M http://purl.org/dc/terms/created 2014-07-03T14:33:40.163+02:00 http://www.tkuhn.ch/bel2nanopub/RAt1kzjmNpOexdZB7flxc6pweQ1nE2-6hsN11QDTRGL1M http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAt1kzjmNpOexdZB7flxc6pweQ1nE2-6hsN11QDTRGL1M http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234