@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAsgVeEmzWCxyif09iNg7vbJucLUNpzv0f94gnF6oIULk> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAsgVeEmzWCxyif09iNg7vbJucLUNpzv0f94gnF6oIULk#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasPart: <http://purl.obolibrary.org/obo/BFO_0000051> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   sub:_1 hasPart: sub:_2 , sub:_3 ;
    a ProteinComplex: .
  sub:_2 geneProductOf: hgnc:3229 ;
    a Protein: .
  sub:_3 geneProductOf: hgnc:3236 ;
    a Protein: .
  sub:_4 hasPart: sub:_5 , sub:_6 , sub:_7 ;
    a ProteinComplex: .
  sub:_5 geneProductOf: hgnc:3229 ;
    a Protein: .
  sub:_6 geneProductOf: hgnc:3236 ;
    a Protein: .
  sub:_7 geneProductOf: hgnc:4566 ;
    a Protein: .
  sub:_8 occursIn: species:9606 ;
    rdf:object sub:_4 ;
    rdf:predicate belv:increases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "complex(p(HGNC:EGF),p(HGNC:EGFR)) -> complex(p(HGNC:EGF),p(HGNC:EGFR),p(HGNC:GRB2))" .
}
sub:provenance {
   beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_10 ;
    pav:version "20131211" .
  sub:_10 rdfs:label "Selventa" .
  sub:_9 prov:value "In the present study the function of Ash/Grb-2 was investigated by microinjecting cells with an anti-Ash antibody. The antibody abolished both S phase entry and the reorganization of actin assembly to ruffle formation upon stimulation with epidermal growth factor (EGF) and platelet-derived growth factor (PDGF). On the other hand, anti-Ash antibody had no effect on S phase entry or actin stress fiber formation induced by either serum or lysophosphatidic acid. Since the induction of DNA synthesis, ruffle induction and stress fiber formation involve a function of Ras, Rac activation and Rho activation respectively, the findings strongly suggest that Ash plays a critical role in the signaling of both pathways downstream from growth factor receptors to Ras and Rac. Consistent with this, Ash co-precipitated with EGF receptor from EGF-stimulated cells." ;
    prov:wasQuotedFrom pubmed:8253073 .
  sub:assertion prov:hadPrimarySource pubmed:8253073 ;
    prov:wasDerivedFrom beldoc: , sub:_9 .
}
sub:pubinfo {
   this: dct:created "2014-07-03T14:33:49.630+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}