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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAsc_t8fggqvOe5cDdZW-FUqYN2xyH2rfD3aGXJnYKa7E#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAsc_t8fggqvOe5cDdZW-FUqYN2xyH2rfD3aGXJnYKa7E#_5 http://www.w3.org/ns/prov#value In this study we demonstrated that Sox9, an essential transcription factor of chondrogenesis, binds to the COMP promoter at the PRE in which 13 nucleotides (TGTTTACCTTGTG) are required for the binding of Sox9. Sox9 activates COMP gene expression and this activation is PRE-dependent. Sox9 is required for COMP gene expression during chondrogenesis, since repression of Sox9 expression using the small interfering RNA approach inhibited COMP gene expression. In addition, activation of COMP gene expression by Sox9 requires the participation of transcription factors Sox5 and Sox6 as well as the coactivators CBP and p300 histone acetylase. It appears that there exists a balance between LRF repressor and Sox9 activator in the control of COMP gene, since transactivation of COMP gene by Sox9 was abolished by the coexpression of LRF, and excess Sox9 overcame the LRF-mediated inhibition. http://www.tkuhn.ch/bel2nanopub/RAsc_t8fggqvOe5cDdZW-FUqYN2xyH2rfD3aGXJnYKa7E#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17485346 http://www.tkuhn.ch/bel2nanopub/RAsc_t8fggqvOe5cDdZW-FUqYN2xyH2rfD3aGXJnYKa7E#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAsc_t8fggqvOe5cDdZW-FUqYN2xyH2rfD3aGXJnYKa7E#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17485346 http://www.tkuhn.ch/bel2nanopub/RAsc_t8fggqvOe5cDdZW-FUqYN2xyH2rfD3aGXJnYKa7E#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAsc_t8fggqvOe5cDdZW-FUqYN2xyH2rfD3aGXJnYKa7E#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAsc_t8fggqvOe5cDdZW-FUqYN2xyH2rfD3aGXJnYKa7E#_5 http://www.tkuhn.ch/bel2nanopub/RAsc_t8fggqvOe5cDdZW-FUqYN2xyH2rfD3aGXJnYKa7E#pubinfo http://www.tkuhn.ch/bel2nanopub/RAsc_t8fggqvOe5cDdZW-FUqYN2xyH2rfD3aGXJnYKa7E http://purl.org/dc/terms/created 2014-07-03T14:33:10.339+02:00 http://www.tkuhn.ch/bel2nanopub/RAsc_t8fggqvOe5cDdZW-FUqYN2xyH2rfD3aGXJnYKa7E http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAsc_t8fggqvOe5cDdZW-FUqYN2xyH2rfD3aGXJnYKa7E http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234