@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAsRnOIr7a2iJOC7aK3fBvaWIScqPNLvpjfhP-v9TfpG0> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAsRnOIr7a2iJOC7aK3fBvaWIScqPNLvpjfhP-v9TfpG0#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0042789 .
  
  sub:_2 geneProductOf: hgnc:11364;
    a Protein: .
  
  sub:_3 hasAgent: sub:_4;
    a go:0003824 .
  
  sub:_4 geneProductOf: hgnc:1509;
    a Protein: .
  
  sub:_5 occursIn: species:9606;
    rdf:object sub:_3;
    rdf:predicate belv:decreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "tscript(p(HGNC:STAT3)) -| cat(p(HGNC:CASP8))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_7;
    pav:version "20131211" .
  
  sub:_6 prov:value "Several studies have further suggested that the upregulation of STAT3 directly confers a drug-resistance phenotype. For example, overexpression of this transcription factor protects epidermal keratinocytes or cervical carcinoma cells from ultraviolet radiation (UV)-induced apoptosis [74,75]. In addition, STAT3 deficiency sensitizes keratinocytes to UV-induced apoptosis. Interestingly, a simple application of a naked STAT3 plasmid on the skin is sufficient to prevent the effect of irradiation. This protective effect was also confirmed in colorectal cancer cell lines where STAT3 inactivation also enhances UV-induced cell death [57]. In multiple myeloma, the aberrant activation of STAT3 has also been shown to confer resistance to FASmediated apoptosis [28]. The inhibition of STAT3 signaling downregulates the expression of survival proteins and restores the sensitivity to cell-death receptors. Furthermore, a constitutively activated form of STAT3 has been shown in vivo to protect liver cells from FAS-mediated apoptosis and necrosis [76]. This has been related to an enhanced expression of anti-apoptotic proteins such as FLICE-inhibitory protein (FLIP), BCL2, or BCL-XL and a downregulation of FADD-like interleukin-1 b-converting enzyme (FLICE) and caspase 3.";
    prov:wasQuotedFrom pubmed:17118707 .
  
  sub:_7 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:17118707;
    prov:wasDerivedFrom beldoc:, sub:_6 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:33:07.015+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}