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p(MGI:Foxd3) -> r(MGI:Dlx5)
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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Examining expression of Sox10, a marker of early NC, revealed reduced expression in the developing trigeminal, facial and vestibulocochlear ganglia and no expression in the glossopharyngeal and vagus ganglia. Sox10 expression was also reduced along the trunk of the embryo (Fig. 3D). Expression of other NC-specific genes {Msx1, Dlx5, Crabp) in the PAs uniformly showed reduced expression in PAs 1 and 2 (see Fig. S1 in the supplementary material). Together, these data suggest that the initial specification of NC occurs in Foxd3 mutants, but there is an overall failure to maintain NC progenitors as demonstrated by a loss of PA-derived structures and a concomitant decrease in expression of NC-specific genes.
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Selventa
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2014-07-03T14:33:18.740+02:00
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