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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAs8tzrkFPz-gX_k6ySZBhx-UIFmI9CF6gUFKZsZZwwmQ#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAs8tzrkFPz-gX_k6ySZBhx-UIFmI9CF6gUFKZsZZwwmQ#_4 http://www.w3.org/ns/prov#value To determine whether paracrine production of IL-6 was responsible for activating the gp130 receptor in these cell lines, conditioned medium (CM) was isolated from 11-18 cells and applied to MCF-10A cells (which do not express pSTAT3) in the absence or presence of various blocking antibodies against gp130, IL-6, IL-6–specific receptor IL-6R, and other gp130 pathway cytokines, OSM and LIF. 11-18 CM induced high levels of pSTAT3, which was inhibited by gp130, IL-6 ligand, or IL-6 receptor antibodies, but not in control IgG-, anti-OSM-, or anti-LIF antibody–treated MCF-10A cells (Figure 4B). http://www.tkuhn.ch/bel2nanopub/RAs8tzrkFPz-gX_k6ySZBhx-UIFmI9CF6gUFKZsZZwwmQ#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18060032 http://www.tkuhn.ch/bel2nanopub/RAs8tzrkFPz-gX_k6ySZBhx-UIFmI9CF6gUFKZsZZwwmQ#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAs8tzrkFPz-gX_k6ySZBhx-UIFmI9CF6gUFKZsZZwwmQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18060032 http://www.tkuhn.ch/bel2nanopub/RAs8tzrkFPz-gX_k6ySZBhx-UIFmI9CF6gUFKZsZZwwmQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAs8tzrkFPz-gX_k6ySZBhx-UIFmI9CF6gUFKZsZZwwmQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAs8tzrkFPz-gX_k6ySZBhx-UIFmI9CF6gUFKZsZZwwmQ#_4 http://www.tkuhn.ch/bel2nanopub/RAs8tzrkFPz-gX_k6ySZBhx-UIFmI9CF6gUFKZsZZwwmQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAs8tzrkFPz-gX_k6ySZBhx-UIFmI9CF6gUFKZsZZwwmQ http://purl.org/dc/terms/created 2014-07-03T14:33:13.894+02:00 http://www.tkuhn.ch/bel2nanopub/RAs8tzrkFPz-gX_k6ySZBhx-UIFmI9CF6gUFKZsZZwwmQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAs8tzrkFPz-gX_k6ySZBhx-UIFmI9CF6gUFKZsZZwwmQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234