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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAs3gL5A9xgaWf9c-_Rgx0-WRJGcHQ6KN9oeQIpx_azHI#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAs3gL5A9xgaWf9c-_Rgx0-WRJGcHQ6KN9oeQIpx_azHI#_4 http://www.w3.org/ns/prov#value Treatment of 50ng/ml NGF for 48 hours increased approximately four-fold APP promoter activity (this induction is mediated by DNA sequences located between the nucleotides -307 and -15). Incubation of PC-12 cells with NGF for 48 hours lead to an increase in the intracellular APP content. Treatment of PC-12 subclone M-M17-26 (which express the dominant inhibitory RAS mutant) with NGF was not able to stimulate the APP promoter activity, showing the requirement of the functional Ras for this response. http://www.tkuhn.ch/bel2nanopub/RAs3gL5A9xgaWf9c-_Rgx0-WRJGcHQ6KN9oeQIpx_azHI#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11359873 http://www.tkuhn.ch/bel2nanopub/RAs3gL5A9xgaWf9c-_Rgx0-WRJGcHQ6KN9oeQIpx_azHI#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAs3gL5A9xgaWf9c-_Rgx0-WRJGcHQ6KN9oeQIpx_azHI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11359873 http://www.tkuhn.ch/bel2nanopub/RAs3gL5A9xgaWf9c-_Rgx0-WRJGcHQ6KN9oeQIpx_azHI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAs3gL5A9xgaWf9c-_Rgx0-WRJGcHQ6KN9oeQIpx_azHI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAs3gL5A9xgaWf9c-_Rgx0-WRJGcHQ6KN9oeQIpx_azHI#_4 http://www.tkuhn.ch/bel2nanopub/RAs3gL5A9xgaWf9c-_Rgx0-WRJGcHQ6KN9oeQIpx_azHI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAs3gL5A9xgaWf9c-_Rgx0-WRJGcHQ6KN9oeQIpx_azHI http://purl.org/dc/terms/created 2014-07-03T14:31:41.778+02:00 http://www.tkuhn.ch/bel2nanopub/RAs3gL5A9xgaWf9c-_Rgx0-WRJGcHQ6KN9oeQIpx_azHI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAs3gL5A9xgaWf9c-_Rgx0-WRJGcHQ6KN9oeQIpx_azHI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234