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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAruRLMAqH1O4CmVwlJqMRDvfZYg1ndZDwG-1-m0tcKlg#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAruRLMAqH1O4CmVwlJqMRDvfZYg1ndZDwG-1-m0tcKlg#_6 http://www.w3.org/ns/prov#value As is evident from Figure 9C, overexpression of WT-SHP2 mimicked the motility stimulatory effect of NO donor, in agreement with our previous publication.13 However, the motogenic effect of SHP2 was blocked when Gab1YF was coexpressed with WT-SHP2. It should be noted that neither of the two adenoviruses affected the expression of the second protein when coinfected in primary cells, as shown by Western blot analysis (Figures 9A and 9B). Because the Gab1YF mutant has been repeatedly shown to have a reduced interaction with SHP2,18,19,36 the results presented in Figure 9C demonstrate that a functional interaction between Gab1 and SHP2 is necessary to explain NO signaling related to increased motility. Moreover, this finding emphasizes that a requirement of Gab1 for SHP2 and of SHP2 for Gab1 is mutual. http://www.tkuhn.ch/bel2nanopub/RAruRLMAqH1O4CmVwlJqMRDvfZYg1ndZDwG-1-m0tcKlg#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14551245 http://www.tkuhn.ch/bel2nanopub/RAruRLMAqH1O4CmVwlJqMRDvfZYg1ndZDwG-1-m0tcKlg#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAruRLMAqH1O4CmVwlJqMRDvfZYg1ndZDwG-1-m0tcKlg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14551245 http://www.tkuhn.ch/bel2nanopub/RAruRLMAqH1O4CmVwlJqMRDvfZYg1ndZDwG-1-m0tcKlg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAruRLMAqH1O4CmVwlJqMRDvfZYg1ndZDwG-1-m0tcKlg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAruRLMAqH1O4CmVwlJqMRDvfZYg1ndZDwG-1-m0tcKlg#_6 http://www.tkuhn.ch/bel2nanopub/RAruRLMAqH1O4CmVwlJqMRDvfZYg1ndZDwG-1-m0tcKlg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAruRLMAqH1O4CmVwlJqMRDvfZYg1ndZDwG-1-m0tcKlg http://purl.org/dc/terms/created 2014-07-03T14:32:09.992+02:00 http://www.tkuhn.ch/bel2nanopub/RAruRLMAqH1O4CmVwlJqMRDvfZYg1ndZDwG-1-m0tcKlg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAruRLMAqH1O4CmVwlJqMRDvfZYg1ndZDwG-1-m0tcKlg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234