@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAruRLMAqH1O4CmVwlJqMRDvfZYg1ndZDwG-1-m0tcKlg> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAruRLMAqH1O4CmVwlJqMRDvfZYg1ndZDwG-1-m0tcKlg#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix rgd: <http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0003824 .
  
  sub:_2 geneProductOf: rgd:1311085;
    a Protein: .
  
  sub:_3 hasAgent: sub:_4;
    a go:0016791 .
  
  sub:_4 geneProductOf: rgd:3447;
    a Protein: .
  
  sub:_5 occursIn: obo:CL_0000192, obo:UBERON_0000947, species:10116;
    rdf:object sub:_3;
    rdf:predicate belv:directlyIncreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "cat(p(RGD:Gab1)) => phos(p(RGD:Ptpn11))" .
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sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_7;
    pav:version "20131211" .
  
  sub:_6 prov:value "As is evident from Figure 9C, overexpression of WT-SHP2 mimicked the motility stimulatory effect of NO donor, in agreement with our previous publication.13 However, the motogenic effect of SHP2 was blocked when Gab1YF was coexpressed with WT-SHP2. It should be noted that neither of the two adenoviruses affected the expression of the second protein when coinfected in primary cells, as shown by Western blot analysis (Figures 9A and 9B). Because the Gab1YF mutant has been repeatedly shown to have a reduced interaction with SHP2,18,19,36 the results presented in Figure 9C demonstrate that a functional interaction between Gab1 and SHP2 is necessary to explain NO signaling related to increased motility. Moreover, this finding emphasizes that a requirement of Gab1 for SHP2 and of SHP2 for Gab1 is mutual.";
    prov:wasQuotedFrom pubmed:14551245 .
  
  sub:_7 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:14551245;
    prov:wasDerivedFrom beldoc:, sub:_6 .
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sub:pubinfo {
  this: dct:created "2014-07-03T14:32:09.992+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}