http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#Head http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#assertion http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#provenance http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#pubinfo http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#assertion http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11055 http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CLO_0003704 http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#_1 http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://amigo.geneontology.org/amigo/term/GO:0001666 http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#assertion http://www.w3.org/2000/01/rdf-schema#label bp(GOBP:"response to hypoxia") -> r(HGNC:SLC6A8) http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#_3 http://www.w3.org/ns/prov#value The full extent to which hypoxia produces gene expression changes in human cells is unknown. We used late-generation oligonucleotide arrays to catalog hypoxia-induced changes in gene expression in HepG2 cells. Five paired sets of cultures were subjected to either control (room air-5% CO(2)) or hypoxic (1% O(2)-5% CO(2)) conditions for 24 h, and RNA was analyzed on an Affymetrix cDNA array containing approximately 12,600 sequences. A statistically significant change in expression was shown by 2,908 sequences (1,255 increased and 1,653 decreased). The observed changes were highly concordant with published literature on hypoxic stress but showed relatively little overlap (12-22%) with changes in gene expression that have been reported to occur after heat stress in other systems. Of note, of these 2,908 sequences, only 387 (213 increased and 174 decreased) both exhibited changes in expression of twofold or greater and were highly expressed in at least three of the five experiments. We conclude that the effect of hypoxia on gene expression by HepG2 cells is broad, has a significant component of downregulation, and includes a relatively small number of genes whose response is truly independent of cell and stress type. http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12464685 http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12464685 http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#_3 http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg#pubinfo http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg http://purl.org/dc/terms/created 2014-07-03T14:31:56.987+02:00 http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RArqXz8BmIWcZ7y1vI7731oZ9iMczOAcRmyF0PfRe9JZg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234