. . . . . . . . . . . . . . . . . . . . "complex(p(MGI:Nfe2),p(MGI:Mafk)) => tscript(p(MGI:Mafk))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "High-level, tissue-specific expression of the beta-globin genes requires the presence of an upstream locus control region (LCR). The overall enhancer activity of the beta-globin complex LCR (beta-LCR) is dependent on the integrity of the tandem NF-E2 sites of HS-2. The NF-E2 protein which binds these sites is a heterodimeric basic leucine zipper protein composed of a tissue-specific subunit, p45 NF-E2, and a smaller subunit, p18 NF-E2, that is widely expressed. .... Reduced levels of both alpha- and beta-globin were associated with the lower levels of NF-E2 activity in this cell line. Globin expression was fully restored upon the introduction of a tethered p45-p18 heterodimer. .... From these results, we conclude that NF-E2 is specifically required for high level goblin gene expression in MEL cells." . . "Selventa" . . . . "2014-07-03T14:33:45.787+02:00"^^ . . .