. . . . . . . . . . . . . . "p(MGI:Dlx5) -> r(EGID:109899)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "An early confluent culture of C2C12 cells pretreated with 10 microg/ml of cycloheximide (CHX) for 30 minutes and then treated with 300ng/ml of BMP-2 (bone morphogenetic protein2) for 1 day induced the expression of Dlx5. Moreover when Dlx5 was over-expressed by transfecting C2C12 cells with the Dlx5 expression vector, Alp expression was stimulated even in the absence of BMP-2 treatment and that Dlx5 and the product of its target gene, Runx2, stimulated ALP promoter activity in an additive manner. However, because Dlx5 continued to stimulate ALP expression in Runx2(-/-) cells, the ALP stimulatory activity of Dlx5 is independent of Runx2. Thus it suggests that Alp is a downstream target of Dlx5 and that Dlx5 and Runx5 can both regulate its expression." . . "Selventa" . . . . "2014-07-03T14:32:32.101+02:00"^^ . . .