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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RArS40tvs--GCkeR4LvHeBcSe1mvS0u1XRWCAYlm10Gbk#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RArS40tvs--GCkeR4LvHeBcSe1mvS0u1XRWCAYlm10Gbk#_5 http://www.w3.org/ns/prov#value Overexpression of Lyn induced constitutive phosphorylation of CrkL and activation of Erk, whereas that of a Lyn mutant lacking the tyrosine kinase domain attenuated the Epo-induced phosphorylation of CrkL and activation of Erk. Furthermore, Lyn, but not Jak2, phosphorylated CrkL on tyrosine in in vitro kinase assays. Together, the present study suggests that, upon Epo stimulation, CrkL is recruited to the EpoR through interaction between the CrkL SH2 domain and phosphorylated Tyr(460) in the EpoR cytoplasmic domain and undergoes tyrosine phosphorylation by receptor-associated Lyn to activate the downstream signaling pathway leading to the activation of Erk and Elk-1. http://www.tkuhn.ch/bel2nanopub/RArS40tvs--GCkeR4LvHeBcSe1mvS0u1XRWCAYlm10Gbk#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11443118 http://www.tkuhn.ch/bel2nanopub/RArS40tvs--GCkeR4LvHeBcSe1mvS0u1XRWCAYlm10Gbk#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RArS40tvs--GCkeR4LvHeBcSe1mvS0u1XRWCAYlm10Gbk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11443118 http://www.tkuhn.ch/bel2nanopub/RArS40tvs--GCkeR4LvHeBcSe1mvS0u1XRWCAYlm10Gbk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RArS40tvs--GCkeR4LvHeBcSe1mvS0u1XRWCAYlm10Gbk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RArS40tvs--GCkeR4LvHeBcSe1mvS0u1XRWCAYlm10Gbk#_5 http://www.tkuhn.ch/bel2nanopub/RArS40tvs--GCkeR4LvHeBcSe1mvS0u1XRWCAYlm10Gbk#pubinfo http://www.tkuhn.ch/bel2nanopub/RArS40tvs--GCkeR4LvHeBcSe1mvS0u1XRWCAYlm10Gbk http://purl.org/dc/terms/created 2014-07-03T14:31:42.529+02:00 http://www.tkuhn.ch/bel2nanopub/RArS40tvs--GCkeR4LvHeBcSe1mvS0u1XRWCAYlm10Gbk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RArS40tvs--GCkeR4LvHeBcSe1mvS0u1XRWCAYlm10Gbk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234