sub:assertion {
d:DB00176 dv:ddi-interactor-in dr:DB00176_DB00382 .
d:DB00382 dv:ddi-interactor-in dr:DB00176_DB00382 .
dr:DB00176_DB00382 dct:identifier "drugbank_resource:DB00176_DB00382" ;
dct:title "DDI between Fluvoxamine and Tacrine - Fluvoxamine, a strong CYP1A2 inhibitor, may decrease the metabolism and clearance of tacrine, a CYP1A2 substrate. Concomitant therapy should be avoided as it could lead to severe toxic effects such as hepatotoxicity. If concomitant therapy is used, monitor for altered efficacy and toxic effects, such as gastrointestinal and hepatic effects, of tacrine."@en ;
a dv:Drug-Drug-Interaction ;
rdfs:label "DDI between Fluvoxamine and Tacrine - Fluvoxamine, a strong CYP1A2 inhibitor, may decrease the metabolism and clearance of tacrine, a CYP1A2 substrate. Concomitant therapy should be avoided as it could lead to severe toxic effects such as hepatotoxicity. If concomitant therapy is used, monitor for altered efficacy and toxic effects, such as gastrointestinal and hepatic effects, of tacrine. [drugbank_resource:DB00176_DB00382]"@en .
}