http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.Head http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ http://www.nanopub.org/nschema#hasAssertion http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.assertion http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ http://www.nanopub.org/nschema#hasProvenance http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.provenance http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ http://www.nanopub.org/nschema#hasPublicationInfo http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.pubinfo http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.assertion http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._1 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._2 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._1 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._3 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/obo/owl/SO#SO_0001148 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#RangedSequencePosition http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._1 http://www.w3.org/2000/01/rdf-schema#comment Loss of endoproteolytic cleavage. Reduces production of amyloid beta in APP processing. Disassembly of the N-cadherin/PS1 complex at the cell surface. Impairs CDH2 processing. http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._2 http://semanticscience.org/resource/SIO_000300 385 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._3 http://semanticscience.org/resource/SIO_000300 385 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._4 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._5 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._4 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._6 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/obo/owl/SO#SO_0001148 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#RangedSequencePosition http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._4 http://www.w3.org/2000/01/rdf-schema#comment Abolishes gamma-secretase activity. Reduces production of amyloid beta in APP processing. Accumulation of full-length PS1. Loss of binding of transition state analog gamma-secretase inhibitor. http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._5 http://semanticscience.org/resource/SIO_000300 385 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._6 http://semanticscience.org/resource/SIO_000300 385 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._6 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._7 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._8 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._7 http://semanticscience.org/resource/SIO_000053 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._9 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._7 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/obo/owl/SO#SO_0001148 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._7 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#RangedSequencePosition http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._7 http://www.w3.org/2000/01/rdf-schema#comment No effect on caspase cleavage. http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._8 http://semanticscience.org/resource/SIO_000300 385 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._8 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#StartPosition http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._9 http://semanticscience.org/resource/SIO_000300 385 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._9 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://sadiframework.org/ontologies/GMOD/RangedSequencePosition.owl#EndPosition http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.assertion http://www.w3.org/2000/01/rdf-schema#comment Mutagenesis site occurs in NX_P49768-1 at amino acids 385 - 385. http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.seqFeature http://purl.obolibrary.org/obo/#BFO_0000066 http://www.nextprot.org/db/search#NX_P49768-1 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.seqFeature http://semanticscience.org/resource/SIO_000008 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._1 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.seqFeature http://semanticscience.org/resource/SIO_000008 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._4 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.seqFeature http://semanticscience.org/resource/SIO_000008 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._7 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.seqFeature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.org/obo/owl/SO#SO_000010 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.provenance http://www.nextprot.org/help/quality_criteria/gold http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000205 http://www.nextprot.org/help/quality_criteria/gold http://www.w3.org/2000/01/rdf-schema#label neXtProt gold http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._10 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.bioassayontology.org/bao#BAO_0002095 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._11 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000218 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._12 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.bioassayontology.org/bao#BAO_0002095 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._13 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000218 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._14 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.bioassayontology.org/bao#BAO_0002095 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._15 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000218 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.assertion http://purl.org/net/provenance/ns#usedData http://www.uniprot.org/uniprot/P49768 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.assertion http://purl.org/ontology/wi/core#evidence http://www.nextprot.org/help/quality_criteria/gold http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.assertion http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000006 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.assertion http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000200 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._10 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._12 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._14 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.assertion http://www.w3.org/ns/prov#wasGeneratedBy http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._11 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.assertion http://www.w3.org/ns/prov#wasGeneratedBy http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._13 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.assertion http://www.w3.org/ns/prov#wasGeneratedBy http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ._15 http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ.pubinfo http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ http://purl.org/dc/terms/created 2014-09-19T00:00:00.0Z http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ http://purl.org/dc/terms/rights http://creativecommons.org/licenses/by/3.0/ http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ http://purl.org/dc/terms/rightsHolder http://nextprot.org http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ http://purl.org/net/provenance/ns#usedData neXtProt database http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ http://swan.mindinformatics.org/ontologies/1.2/pav/authoredBy CALIPHO project http://www.nextprot.org/nanopubs#NX_P49768-1_MUTAGEN_385_385.RArE_Op-xw9ezGMMhlTr2AGNBg1er69pSSMu2X3JEguCQ http://swan.mindinformatics.org/ontologies/1.2/pav/authoredBy http://orcid.org/0000-0001-6710-1373 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