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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAr647OJ15f5oBRA5xNtRxwUFLP4PN1deTQBYrenC6Xvg#_3 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAr647OJ15f5oBRA5xNtRxwUFLP4PN1deTQBYrenC6Xvg#_2 http://www.w3.org/ns/prov#value Recent studies in a variety of species including mammals showed that resveratrol (trans-3, 5, 4''-trihydroxystibene) treatment and caloric restriction increased silent information regulator 2/sirtuin 1 activity, which mediated increase in life span/cell survival. Resveratrol is a naturally occurring phytoalexin and a well-documented cardioprotective agent. Similarly, ischemic preconditioning (IPC) has been shown to be both cardio- and cerebroprotective against subsequent ischemic insults. A major emphasis in this field is to understand the molecular mechanisms that mediate this phenomenon. The goal of this study was to define whether resveratrol can emulate IPC neuroprotection against cerebral ischemia. Employing an in vitro model of cerebral ischemia, the organotypic hippocampal slice culture, we report that resveratrol pretreatment mimics IPC via the SIRT1 pathway. Blockade of SIRT1 activation by sirtinol after IPC or resveratrol pretreatment abolished their neuroprotection. A better understanding of the mechanisms by which resveratrol induces ischemic tolerance in a prophylactic manner may provide a novel therapy against stroke or neurosurgical procedures. http://www.tkuhn.ch/bel2nanopub/RAr647OJ15f5oBRA5xNtRxwUFLP4PN1deTQBYrenC6Xvg#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16395277 http://www.tkuhn.ch/bel2nanopub/RAr647OJ15f5oBRA5xNtRxwUFLP4PN1deTQBYrenC6Xvg#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAr647OJ15f5oBRA5xNtRxwUFLP4PN1deTQBYrenC6Xvg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16395277 http://www.tkuhn.ch/bel2nanopub/RAr647OJ15f5oBRA5xNtRxwUFLP4PN1deTQBYrenC6Xvg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAr647OJ15f5oBRA5xNtRxwUFLP4PN1deTQBYrenC6Xvg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAr647OJ15f5oBRA5xNtRxwUFLP4PN1deTQBYrenC6Xvg#_2 http://www.tkuhn.ch/bel2nanopub/RAr647OJ15f5oBRA5xNtRxwUFLP4PN1deTQBYrenC6Xvg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAr647OJ15f5oBRA5xNtRxwUFLP4PN1deTQBYrenC6Xvg http://purl.org/dc/terms/created 2014-07-03T14:32:54.717+02:00 http://www.tkuhn.ch/bel2nanopub/RAr647OJ15f5oBRA5xNtRxwUFLP4PN1deTQBYrenC6Xvg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAr647OJ15f5oBRA5xNtRxwUFLP4PN1deTQBYrenC6Xvg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234