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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAr2nAMv6NtqEFKTBG3-ND4WYBn7-hgTwgap8xkcKgUmc#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAr2nAMv6NtqEFKTBG3-ND4WYBn7-hgTwgap8xkcKgUmc#_4 http://www.w3.org/ns/prov#value In Lmx1b-/- embryos, the expression of Wnt1, En1 and Pax2 was drastically reduced in the MHB at the 3-somite stage (Fig. 4F,J,N), whereas they were highly expressed in the wild-type embryo (Fig. 4E,I,M). The expression was lost altogether by E9.5 (Fig. 4H,L,P). Because the reduction in Wnt1, En1 and Pax2 expression occurred before the absence of Fgf8 in the Lmx1b-/- embryo, the reduction should have resulted from the inactivation of Lmx1b, rather than of Fgf8. Furthermore, we found that En2 expression, which is normally expressed later than Fgf8, was also downregulated but maintained at a low level until at least E9.5 (data not shown). Thus, the expression of Wnt1, En1 and Pax2 did not appear to be causally related to Fgf8 expression, whereas En2 expression may depend on Fgf8 expression. Nevertheless, it is clear that Lmx1b expression, although not required for the initiation of Wnt1, En1, En2 and Pax2 expression, is necessary for their maintenance in the MHB. http://www.tkuhn.ch/bel2nanopub/RAr2nAMv6NtqEFKTBG3-ND4WYBn7-hgTwgap8xkcKgUmc#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17166916 http://www.tkuhn.ch/bel2nanopub/RAr2nAMv6NtqEFKTBG3-ND4WYBn7-hgTwgap8xkcKgUmc#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAr2nAMv6NtqEFKTBG3-ND4WYBn7-hgTwgap8xkcKgUmc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17166916 http://www.tkuhn.ch/bel2nanopub/RAr2nAMv6NtqEFKTBG3-ND4WYBn7-hgTwgap8xkcKgUmc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAr2nAMv6NtqEFKTBG3-ND4WYBn7-hgTwgap8xkcKgUmc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAr2nAMv6NtqEFKTBG3-ND4WYBn7-hgTwgap8xkcKgUmc#_4 http://www.tkuhn.ch/bel2nanopub/RAr2nAMv6NtqEFKTBG3-ND4WYBn7-hgTwgap8xkcKgUmc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAr2nAMv6NtqEFKTBG3-ND4WYBn7-hgTwgap8xkcKgUmc http://purl.org/dc/terms/created 2014-07-03T14:33:07.591+02:00 http://www.tkuhn.ch/bel2nanopub/RAr2nAMv6NtqEFKTBG3-ND4WYBn7-hgTwgap8xkcKgUmc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAr2nAMv6NtqEFKTBG3-ND4WYBn7-hgTwgap8xkcKgUmc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234