@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAr2nAMv6NtqEFKTBG3-ND4WYBn7-hgTwgap8xkcKgUmc> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAr2nAMv6NtqEFKTBG3-ND4WYBn7-hgTwgap8xkcKgUmc#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: mgi:1100513;
    a Protein: .
  
  sub:_2 geneProductOf: mgi:95390;
    a Protein: .
  
  sub:_3 occursIn: obo:UBERON_0005291, species:10090;
    rdf:object sub:_2;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(MGI:Lmx1b) -> p(MGI:En2)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_5;
    pav:version "20131211" .
  
  sub:_4 prov:value "In Lmx1b-/- embryos, the expression of Wnt1, En1 and Pax2 was drastically reduced in the MHB at the 3-somite stage (Fig. 4F,J,N), whereas they were highly expressed in the wild-type embryo (Fig. 4E,I,M). The expression was lost altogether by E9.5 (Fig. 4H,L,P). Because the reduction in Wnt1, En1 and Pax2 expression occurred before the absence of Fgf8 in the Lmx1b-/- embryo, the reduction should have resulted from the inactivation of Lmx1b, rather than of Fgf8. Furthermore, we found that En2 expression, which is normally expressed later than Fgf8, was also downregulated but maintained at a low level until at least E9.5 (data not shown). Thus, the expression of Wnt1, En1 and Pax2 did not appear to be causally related to Fgf8 expression, whereas En2 expression may depend on Fgf8 expression. Nevertheless, it is clear that Lmx1b expression, although not required for the initiation of Wnt1, En1, En2 and Pax2 expression, is necessary for their maintenance in the MHB.";
    prov:wasQuotedFrom pubmed:17166916 .
  
  sub:_5 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:17166916;
    prov:wasDerivedFrom beldoc:, sub:_4 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:33:07.591+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}