. . . . . . . . . . . . . . . . . . "a(CHEBI:nicotine) -> kin(p(SFAM:\"AKT Family\"))" . "a(SCHEM:\"LY 294002\") -| (a(CHEBI:nicotine) -> kin(p(SFAM:\"AKT Family\")))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "To confirm that increased Akt phosphorylation at S473 and T308 was indicative of increased kinase activity, we measured the phosphorylation of an exogenous peptide substrate, glycogen synthase kinase-3?/? (GSK-3?/?), after nicotine or NNK administration (Figure 2a). Nicotine or NNK increased Akt kinase activity in a PI3K-dependent manner, since the PI3K inhibitor LY294002 (18) inhibited induction of Akt activity by nicotine or NNK." . . "Selventa" . . . . "2014-07-03T14:31:57.807+02:00"^^ . . .