http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#Head http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#assertion http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#provenance http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#assertion http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_2 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_3 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_4 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3229 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_3 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3236 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_4 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=4566 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_5 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_6 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0005525 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_6 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=9801 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_7 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_7 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_5 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_7 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_7 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_1 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_7 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#assertion http://www.w3.org/2000/01/rdf-schema#label complex(p(HGNC:EGF),p(HGNC:EGFR),p(HGNC:GRB2)) -> gtp(p(HGNC:RAC1)) http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_9 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_8 http://www.w3.org/ns/prov#value In the present study the function of Ash/Grb-2 was investigated by microinjecting cells with an anti-Ash antibody. The antibody abolished both S phase entry and the reorganization of actin assembly to ruffle formation upon stimulation with epidermal growth factor (EGF) and platelet-derived growth factor (PDGF). On the other hand, anti-Ash antibody had no effect on S phase entry or actin stress fiber formation induced by either serum or lysophosphatidic acid. Since the induction of DNA synthesis, ruffle induction and stress fiber formation involve a function of Ras, Rac activation and Rho activation respectively, the findings strongly suggest that Ash plays a critical role in the signaling of both pathways downstream from growth factor receptors to Ras and Rac. Consistent with this, Ash co-precipitated with EGF receptor from EGF-stimulated cells. http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_8 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/8253073 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_9 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/8253073 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#_8 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM http://purl.org/dc/terms/created 2014-07-03T14:33:49.632+02:00 http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAqyQWnlrATRbPVTs6mfWBypJgZc6neauAyaj0SFA_qOM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234