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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAqxCNCvzf72LJW2yDvtMaX5kkPOWi3uKgR1J8DWYVQ0Q#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAqxCNCvzf72LJW2yDvtMaX5kkPOWi3uKgR1J8DWYVQ0Q#_6 http://www.w3.org/ns/prov#value Activated Yes rapidly associates with the EGFR and triggers its phosphorylation at tyrosine residues Tyr845 and Tyr1173. EGFRTyr845 is a known Src target (52), whereas Tyr1173 reflects an activating autophosphorylation site of the EGFR (53). Yes inhibition by SU6656 abolishes EGFR phosphorylation at both sites, whereas AG1478 inhibits EGFR-Tyr1173 phosphorylationbut not phosphorylation at Tyr845. These findings suggest that Yes activates the EGFR at Tyr845, which is followed by activating autophosphorylation at Tyr1173. http://www.tkuhn.ch/bel2nanopub/RAqxCNCvzf72LJW2yDvtMaX5kkPOWi3uKgR1J8DWYVQ0Q#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15917250 http://www.tkuhn.ch/bel2nanopub/RAqxCNCvzf72LJW2yDvtMaX5kkPOWi3uKgR1J8DWYVQ0Q#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAqxCNCvzf72LJW2yDvtMaX5kkPOWi3uKgR1J8DWYVQ0Q#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15917250 http://www.tkuhn.ch/bel2nanopub/RAqxCNCvzf72LJW2yDvtMaX5kkPOWi3uKgR1J8DWYVQ0Q#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAqxCNCvzf72LJW2yDvtMaX5kkPOWi3uKgR1J8DWYVQ0Q#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAqxCNCvzf72LJW2yDvtMaX5kkPOWi3uKgR1J8DWYVQ0Q#_6 http://www.tkuhn.ch/bel2nanopub/RAqxCNCvzf72LJW2yDvtMaX5kkPOWi3uKgR1J8DWYVQ0Q#pubinfo http://www.tkuhn.ch/bel2nanopub/RAqxCNCvzf72LJW2yDvtMaX5kkPOWi3uKgR1J8DWYVQ0Q http://purl.org/dc/terms/created 2014-07-03T14:32:45.305+02:00 http://www.tkuhn.ch/bel2nanopub/RAqxCNCvzf72LJW2yDvtMaX5kkPOWi3uKgR1J8DWYVQ0Q http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAqxCNCvzf72LJW2yDvtMaX5kkPOWi3uKgR1J8DWYVQ0Q http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234