sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_7 ; pav:version "20131211" . sub:_6prov:value "Activated Yes rapidly associates with the EGFR and triggers its phosphorylation at tyrosine residues Tyr845 and Tyr1173. EGFRTyr845 is a known Src target (52), whereas Tyr1173 reflects an activating autophosphorylation site of the EGFR (53). Yes inhibition by SU6656 abolishes EGFR phosphorylation at both sites, whereas AG1478 inhibits EGFR-Tyr1173 phosphorylationbut not phosphorylation at Tyr845. These findings suggest that Yes activates the EGFR at Tyr845, which is followed by activating autophosphorylation at Tyr1173." ; prov:wasQuotedFrompubmed:15917250 . sub:_7rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:15917250 ; prov:wasDerivedFrombeldoc: , sub:_6 . }