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@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
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@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
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@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
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@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix do: <http://disease-ontology.org/term/DOID:> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
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    a np:Nanopublication .
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sub:assertion {
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  sub:_2 occursIn: do:1936, obo:UBERON_0001969, species:9606;
    rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject go:0006954;
    a rdf:Statement .
  
  sub:assertion rdfs:label "bp(GOBP:\"inflammatory response\") -> r(HGNC:HMOX1)" .
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sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "20131211" .
  
  sub:_3 prov:value "Induction of HO-1 corresponds to a significant suppression of inflammation, whereas inhibition of the enzyme potentiates the inflammatory response in several models of inflammation (Amersi et al., 1999; Nath, 1999; Vogt et al., 1996; Agarwal and Nick, 2000; Willis et al., 2000; Wagener et al., 2001b). These include corneal, lung, and renal inflammatory models, and in transplantation biology (Laniado-Schwartzman et al., 1997; Platt and Nath, 1998; Otterbein et al., 1999a; Agarwal and Nick, 2000).      View larger version (19K): [in this window] [in a new window] FIG. 6. This diagram demonstrates the intricate relationships of HO-1, TNF-, and the heme proteins iNOS and COX during inflammation in a pleurisy model. During inflammation, TNF-, COX, and iNOS get induced, adhesion molecule expression increases, and leukocytes are recruited (Willis et al., 1996, 2000; Wagener et al., 2001b). HO-1 is up-regulated during the resolution of inflammation and controls the activity of the heme proteins COX and NOS both on the level of the prosthetic group heme, as well as by the generation of CO, which can bind to the heme group and alter the activity of the enzymes.  ";
    prov:wasQuotedFrom pubmed:12869663 .
  
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sub:pubinfo {
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