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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAqeS9SfZcEVmISqo-MrTYs5sdeg7dT6nn6euP_Vo0Ci4#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAqeS9SfZcEVmISqo-MrTYs5sdeg7dT6nn6euP_Vo0Ci4#_3 http://www.w3.org/ns/prov#value We demonstrate here, that in HeLa cells, apoptosis is triggered by H(2)O(2) via the mitochondrial pathway involving upregulation of p73, and its downstream target Bax. This was accompanied by upregulation of ERK, JNK, c-Myc, Hsp-70 and down regulation of anti-apoptotic Bcl-XL, release of cytochrome c from mitochondria and activation of caspases-9 and -3. http://www.tkuhn.ch/bel2nanopub/RAqeS9SfZcEVmISqo-MrTYs5sdeg7dT6nn6euP_Vo0Ci4#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17855174 http://www.tkuhn.ch/bel2nanopub/RAqeS9SfZcEVmISqo-MrTYs5sdeg7dT6nn6euP_Vo0Ci4#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAqeS9SfZcEVmISqo-MrTYs5sdeg7dT6nn6euP_Vo0Ci4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17855174 http://www.tkuhn.ch/bel2nanopub/RAqeS9SfZcEVmISqo-MrTYs5sdeg7dT6nn6euP_Vo0Ci4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAqeS9SfZcEVmISqo-MrTYs5sdeg7dT6nn6euP_Vo0Ci4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAqeS9SfZcEVmISqo-MrTYs5sdeg7dT6nn6euP_Vo0Ci4#_3 http://www.tkuhn.ch/bel2nanopub/RAqeS9SfZcEVmISqo-MrTYs5sdeg7dT6nn6euP_Vo0Ci4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAqeS9SfZcEVmISqo-MrTYs5sdeg7dT6nn6euP_Vo0Ci4 http://purl.org/dc/terms/created 2014-07-03T14:33:12.449+02:00 http://www.tkuhn.ch/bel2nanopub/RAqeS9SfZcEVmISqo-MrTYs5sdeg7dT6nn6euP_Vo0Ci4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAqeS9SfZcEVmISqo-MrTYs5sdeg7dT6nn6euP_Vo0Ci4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234