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[AURKB, MELK, PLK1 and TTK), and DNA-damage response genes (e.g.RFC4 and FEN1). siRNA-mediated knockdown of RFC4 significantly reduced cell proliferation in ER-negative normal breast and cancer lines, thereby indicating that RFC4 is essential for both normal and cancer cell survival but could be a useful biomarker for aggressive (ER-negative) breast tumours.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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